Cmt disease

Currently incurable, this disease is the most . Charcot–Marie–Tooth disease. Structural foot deformities such as high arches and hammertoes are common. Axons send chemical messages that attract Schwann cells and encourage myelin formation, and Schwann cells appear to send messages that nourish and protect axons.

This section presents a general picture of CMT signs and symptoms.

They control the muscles and relay . Symptoms can vary depending on the type of CMT and even people with the same type can experience it differently. In almost all cases, the longest nerve fibers are affected first. Over time, affected individuals may lose the normal use of their feet, hands, legs and arms.

Common red flags can include decreased sensitivity to heat, touch or pain, . CMT affects an estimated in 5people in the United States and 2. STOCK_WheelchairWheelClose_thumb.

Inherited means that something can be passed on from generation to generation. Neuropathy means that there is a problem with the nerves. CMT is an inherited peripheral neuropathy.

Peripheral refers to the peripheral nervous system, which . These nerves connect the central nervous system to the rest of the body. Interrupting messages to your brain about things around you, like touch. These symptoms often first appear during adolescence or early adulthoo but can develop later in life, as well. It also affects cells that support and protect nerves.

CMT disease usually affects the nerves that control movement and sensation. As a result, muscle tissue begins to . The first sign of CMT is . Although there is currently no cure, people with CMT can use a variety of therapies and strategies to help manage their symptoms. Clinical presentation Signs and symptoms usually bec. Health Service Information.

More than different genes that cause CMT have been identifie several by Penn clinician-scientists.

Collectively, the various forms of CMT are among the most common, inherited diseases of the nervous . Symptoms include foot deformities, weakness of the lower leg and foot muscles, and difficulty walking, breathing, and swallowing. Researchers now believe that vitamin C maybe able to help this debilitating condition. PETER I inherited CMT from my maternal grandfather.

CMT develops because of a defective gene that causes abnormalities in the nerves that go to the feet, legs, hands and arms. CMT, which is named after the three doctors who first described the disease in . Many of the primary hereditary neuropathies were divided into hereditary motor sensory neuropathy (HMSN) and hereditary sensory autonomic neuropathy ( HSAN). Here five men and women speak about living with C. For a person to be affected with CMT, that person must have one (or two, depending on the type of CMT ) disease causing mutation in one of the genes that causes CMT. There are at least forty different genes that cause CMT when mutated.

A mutation in any one of them can cause the disease.